The Orthomolecular Guy

The Orthomolecular Guy

Protocol Series #1-Presenting a comprehensive protocol for Chronic Kidney Disease

CKD Part 4: A step by step guide of the most extensively researched modalities that treat, manage, delay, and even reverse kidney disease.

Kevin Kirkpatrick MSc.'s avatar
Kevin Kirkpatrick MSc.
Sep 24, 2025
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Introduction:

This is part 4 of my chronic kidney disease series, and the final installment on kidney health. Let’s very briefly review the series before we dive into the protocol.

Part 1 introduced chronic kidney disease primarily as a function of metabolic diseases, such as hypertension, type 2 diabetes, and metabolic syndrome. Along with weight loss, I presented the research on NAC as a strong therapeutic for kidney recovery. CLICK HERE TO READ IT

Part 2 discussed the gut-kidney axis, which described the vicious cycle of gut dysbiosis and CKD, with each worsening the other and driving a disease state. CLICK HERE TO READ IT

Part 3 looks at 9 different treatment modalities for chronic kidney disease that featured the most solid clinical evidence for improvement of kidney labs, delay of disease progression, and lifestyle improvement. CLICK HERE TO READ IT

Part 4 is going to be a continuation of Part 3, in which the research on the various treatment modalities will be fleshed out with clear and actionable instructions on how to implement them. Those modalities are:

Probiotics, prebiotics, synbiotics, NAC, vitamin E, berberine, Huang Qi, Fish Oil, vitamin D, and weight loss.

*To be very clear, I am not suggesting that anyone reading this SHOULD do any of these things. Rather, it is simply a presentation of the protocols laid out in the research presented in part 3. I am not a doctor or a dietician, and this information is for educational and entertainment purposes only and is not meant to serve as a diagnosis or treatment of any disease. Rather, this protocol is for my readers to share with their doctors and registered dieticians, nurse practitioners, or other medical professionals, and to seek their advice on how to implement these modalities, in light of their unique situations.

Also, the research that I have done in the first three parts of this series, and the protocol laid out in this installment, is narrowly focused on the early stages of kidney disease. It is here in stages 1-5 that the research shows the most promise in reversing, managing, and slowing down the progression. The end goal is to never end up with ESRD and dialysis, or even to see improvements in the labs and reverse the course of the disease! Like with diabetes, I know that the miracle of healing is available for anyone who is willing to think outside of the box and do the hard work of lifestyle change. It’s all there in the research and the protocols discussed in that research, which led to successful outcomes, will be presented in a practical way.

The secondary goal is prevent the all but inevitable development of heart disease and chronic vitamin D deficiency that accompanies most cases of CKD.

I am hugely passionate about this topic because my dear father who passed away earlier this year had chronic kidney disease and his experience has fueled my passion to get better information out there, as I feel that his doctors let him down. He was a doctor, and a brilliant one, but he was never told any of the information I am going to share with you below.

This post will be my first post behind a paywall, since it is so detailed and specific, and useful to any medical or nutrition professional in crafting an effective protocol to manage their clients’ kidney disease. Also, I will give examples of specific products that I have found to be successful for myself, my family, and various coaching clients over the years. It’s important to mention that I receive no royalties and have no sponsorships, and am not compensated in any way by any supplement retailer. There are no affiliate links to click. This newsletter is supported by my readers, and any supplement I recommend is because I think it’s a good choice for effectiveness and value.

There are two ways to see the protocol

  1. Become a monthly or annual subscriber here on substack. This will also unlock all future protocol posts, and access to the group chat and future live q and a sessions.

  2. Click on the buy me a coffee link above and make a one time donation to support my work, and I will email you the article.

Thank you so much for your support. I take it very seriously, and am providing information that will change/save/prolong/ lives, and it is well worth it.

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